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Nifedipine-containing nucleated tablet and method for producing the same
专利权人:
バイエル薬品株式会社
发明人:
山之内 由佳,福井 康祐
申请号:
JP2008273941
公开号:
JP5351490B2
申请日:
2008.10.24
申请国别(地区):
JP
年份:
2013
代理人:
摘要:
A sustained release nifedipine-containing press coated tablet, which comprises (A) a core comprising nifedipine and a hydrophilic gel-forming high molecular substance, wherein the dissolution of the nifedipine from the core is designed to be delayed: and (B) an outer shell coating said core, which comprises (i) (a) nifedipine and (b) a disintegration suppression substance comprising a pH-independent water-insoluble polymer, wherein the combined contents of (a) and (b) are in the range of 8 to 22% by weight based on the total weight of the outer shell, and (ii) a hydrophilic gel-forming high molecular substance selected from cellulose derivatives and polyvinyl alcohols, wherein the content thereof is in the range of 76 to 95% by weight based on the total weight of the outer shell, which is characterized in that the diameter of said tablet is 7.5 to 8.5 mm, and the thickness thereof is 4.5 to 5.2 mm, and further characterized in that the dissolution rate of nifedipine from said tablet is controlled within a specific range. The tablet of the present invention is miniaturized as compared to the currently-used nifedipine-containing tablets but the dissolution properties and bioavailability of nifedipine therein are not changed.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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