MACDONALD, LYNN,STEVENS, SEAN,GURER, CAGAN,MURPHY, ANDREW J.,HOSIAWA, KAROLINA A.
申请号：
CA2804311
公开号：
CA2804311C
申请日:
2011.06.22
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
Genetically modified mice are provided that express human ? variable (hV?) sequences, including mice that express hV? sequences from an endogenous mouse ? light chain locus, mice that express hV? sequences from an endogenous mouse ? light chain locus, and mice that express hV? sequences from a transgene or an episome wherein the hV? sequence is linked to a mouse constant sequence. Mice are provided that are a source of somatically mutated human ? variable sequences useful for making antigen- binding proteins. Compositions and methods for making antigen-binding proteins that comprise human ? variable sequences, including human antibodies, are provided.
