A catheter and dressing assembly is disclosed including a dressing having a distal adhesive plate configured for attachment to a skin region surrounding a catheter insertion site to provide a first circumferential seal around the catheter at the insertion site, a dressing body extending from the adhesive plate and configured to surround a catheter segment external to the insertion site and a proximal sealing element. The assembly further includes a two-part catheter having a first distal part consisting of a hub base bonded to a tubular catheter body； and a second proximal interconnector-cap that is adapted to couple to the distal hub base, whereby the attachment of the interconnector-cap to the hub-tubular body portion of the catheter establishes at least one continuous fluid pathway extending from a proximal end of the interconnector-cap to a lumen of the catheter and wherein either the hub base or the interconnector cap further comprises a mating feature for mating to the proximal sealing element of the dressing such that the dressing and interconnector-cap provide a second circumferential seal around the catheter body.
