The present disclosure provides modified adeno-associated virus (AAV) virions with altered capsid proteins, where the modified AAV virions exhibit greater infectivity of retinal cells when administered to the eye or greater infectivity of liver cells when administered intravenously. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, methods of treating ocular diseases and disorders, methods of delivering a gene product to the liver in an individual, and methods of treating liver diseases and disorders.
