Disclosed is a compound represented by the general formula (I), which has a strong COMT inhibitory effect, or a pharmacologically acceptable salt thereof. Also disclosed are a pharmaceutical composition containing the compound or a pharmacologically acceptable salt thereof, and uses of the compound, a pharmacologically acceptable salt of the compound and the pharmaceutical composition. [In the formula (I), R and R respectively represent a hydrogen, a lower acyl, a lower alkoxycarbonyl or the like； R represents a halogenated lower alkyl, a lower acyl, a halogenated lower alkylcarbonyl, a cycloalkylcarbonyl, an optionally substituted arylcarbonyl, a lower alkoxycarbonyl or the like； and R represents a lower alkyl, a halogenated lower alkyl, a cycloalkyl, a lower alkoxy-lower alkyl or the like.]
