There is described a method for sterilizing a device. The method includes: masking a portion of the device from a sterilization protocol using a mask sterilizing a portion of the device using a first sterilization protocol and sterilizing a portion of the device using a second sterilization protocol where the mask shields the masked portion of the device from at least one of the sterilization protocols or attenuates the effect of at least one of the sterilization protocols in the masked portion. There is also described a system for sterilizing a device. The system includes a first sterilant a second sterilant and a mask for shielding a portion of the device from at least one of the sterilants.