Nicolas DESROY,Bertrand HECKMANN,Reginald Christophe Xavier BRYS,Agnès Marie JONCOUR,Christophe PEIXOTO,Xavier Marie BOCK,Christopher Gaëtan HOUSSEMAN
申请号：
US15706073
公开号：
US20180127425A1
申请日:
2017.09.15
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention discloses compounds according to Formula I:Wherein R1a, R1b, R2, R4, R5, R6, R7, R8, W, X, Y, Z, Cy, and the subscript a are as defined herein. The present invention relates to compounds inhibiting autotaxin (NPP2 or ENPP2), methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of diseases involving fibrotic diseases, proliferative diseases, inflammatory diseases, autoimmune diseases, respiratory diseases, cardiovascular diseases, neurodegenerative diseases, dermatological disorders, and/or abnormal angiogenesis associated diseases by administering the compound of the invention.
