Materials and Methods Useful for Affecting Tumor Cell Growth, Migration and Invasion

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专利权人:

发明人:

Carlo M. Croce

申请号：

US14577118

公开号：

US20150104412A1

申请日:

2014.12.19

申请国别(地区):

US

年份:

2015

代理人:

摘要：

It is disclosed herein that miR-221 and miR-222 down-regulate PTEN and TIMP3 tumor suppressors, resulting in TRAIL resistance. The present invention provides research, diagnostic, and therapeutic tools and methods related to this discovery. Diagnostics, prognostics and treatments for human hepatocellular cancer and non-small cell lung carcinoma having a TRAIL resistance are particularly described herein.

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