GEKELER, VOLKER,MAIER, THOMAS,ZIMMERMANN, ASTRID,HOFMANN, HANS-PETER,KULKARNI, SANJEEV A
申请号：
NZ58818309
公开号：
NZ588183A
申请日:
2009.03.23
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed is a compound of formula (I) where the substituents are as disclosed in the specification. Examples of compound of formula (I) are: N-[4-(4-amino-2-ethyl-1H-imidazo [4,5-c]quinolin-1-yl) butyl]-N-(1,1-dioxidotetrahydro-3-thienyl) acetamide, N-[4-(4-amino-2-ethyl-1H-imidazo[ 4,5-c ]quinolin-1-yl)butyl]-N-(1-methyl-1-oxidopiperidin-4-yl)acetamide, 3-{ acetyl[4-(4-amino-2-ethyl-1H-imidazo[4,5-c ]quinolin-1-yl)butyl] amino} -2,5-anhydro-1,3,4-trideoxypentitol, and N-[4-(4-amino-2-ethyl-1H -imidazo[4,5-c]quinolin-1-yl)butyl]-N-(l-benzyl-2-methyl-1-oxidopyrrolidin-3-yl) acetamide. Also disclosed is a pharmaceutical composition comprising a compound of formula (I) and the use of a compound of formula (I) in the manufacture of a medicament for activation of TLR7, treating viral or neoplastic disease or cancer and for the use as an immune response modifier； to stimulate natural killer cell activity, activate macrophages, cause proliferation and differentiation of B-lymphocytes； as a vaccine adjuvant for cell mediated immunity； or to enhance or stimulate the healing of wounds, including chronic wounds.
