599446 Disclosed is a compound of formula (I) where the substituents are as disclosed in the specification. Examples of compound of formula (I) are: 2-ethyl-1-[4-(tetrahydro-2H-pyran-4-ylamino)butyl]-1H-imidazo[4,5-c]quinolin-4-amine, 1-[4-(1-azabicyclo[2.2.2]oct-3-ylamino)butyl]-2-ethyl-1H-imidazo[4,5-c]quinolin-4-amine and1-{ 4-[(1,1-dioxido-3,4-dihydro-2H-thiochromen-4-yl)amino]butyl} -2-ethyl-1Himidazo[4,5-c]quinolin-4-amine. Also disclosed is a pharmaceutical composition comprising a compound of formula (I) and the use of a compound of formula (I) in the manufacture of a medicament for activation of TLR7, treating viral or neoplastic disease or cancer and for the use as an immune response modifier to stimulate natural killer cell activity, activate macrophages, cause proliferation and differentiation of B-lymphocytes as a vaccine adjuvant for cell mediated immunity or to enhance or stimulate the healing of wounds, including chronic wounds.
