PROBLEM TO BE SOLVED: To provide a method that makes it possible to efficiently produce disintegrative particles having a desired particle size distribution.SOLUTION: A method for producing a disintegrative particle includes the steps of (A) conducting an agitating, rolling and granulating process of a primary particle, at least partially insoluble in water, by using aqueous solution of polyvinyl alcohol or a derivative thereof, and (B) conducting a fluid bed drying process of the granule obtained in step (A) at an air velocity of 0.4-1.2 m/s.SELECTED DRAWING: None【課題】所望の粒度分布を有する崩壊性粒子を効率良く製造することのできる方法の提供。【解決手段】(A)少なくとも一部が水不溶性である一次粒子を、ポリビニルアルコール又はその誘導体の水溶液を用いて撹拌転動造粒する工程と、(B)工程(A)で得た造粒物を0.4~1.2m/sの風速で流動層乾燥する工程とを含む、崩壊性粒子の製造方法。【選択図】なし
