Adnan M. M. Mjalli,Anitha Hari,Bapu Gaddam,Devi Reddy Gohimukkula,Dharma Rao Polisetti,Mohan Rao,Raju Bore Gowda,Robert Carl Andrews,Rongyuan Xie,Soumya P. Sahoo,Tan Ren,William Kenneth Banner
申请号：
US13052544
公开号：
US08450354B2
申请日:
2011.03.21
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention provides substituted imidazo[1,2-b]pyridazine derivatives, pharmaceutically acceptable salts thereof, and tautomers of any of the foregoing, where such compounds inhibit β-site amyloid precursor protein-cleaving enzyme (BACE), which may be useful in the treatment of diseases in which BACE is involved, such as Alzheimers disease. The invention also provides pharmaceutical compositions comprising any of these compounds and the use of any of these compounds and compositions in the treatment of diseases, disorders, or conditions in which BACE is involved.
