Referring to a pyrazole Derivative of formula (i), wherein R1 is CN, halogen, alkyl of C1 - C6, among others R2 is H or c1-c6 alkyl, cyano optionally substituted by Halogen.Preferred compounds are: 1 - {5 - [(4-fluorophenyl) sulfonyl] - 1 - (2 - fluoropiridin - 3 - yl) - 1H pyrazole - 3 - il n-methylmethanamine} - {- 1, 1 - (2-fluorophenyl) - 3 - [(IL) - 5 - 4 - 4-methoxyphenyl) sulfonyl] - 1H pyrazole - 3 - il n-methylmethanamine} - {- 1, 1 - (2 - fluoropiridin - 3 - yl) - 5 - [(3-methylphenyl) sulfonyl] - 1H pyrazole - il - 3} - n-methylmethanamine, Among others. It also relates to a Pharmaceutical composition.These compounds inhibit the Proton Pump by suppressing the secretion of gastric acid and are useful in the treatment of Peptic Ulcer, functional dyspepsia, gastroesophageal reflux disease, gastritis, among othersREFERIDA A UN DERIVADO DE PIRAZOL DE FORMULA (I), DONDE R1 ES CN, HALOGENO, ALQUILO C1-C6, ENTRE OTROS R2 ES H, CIANO O ALQUILO C1-C6 OPCIONALMENTE SUSTITUIDO CON HALOGENO. SON COMPUESTOS PREFERIDOS: 1-{5-[(4-FLUOROFENIL)SULFONIL]-1-(2-FLUOROPIRIDIN-3-IL)-1H-PIRAZOL-3-IL}-N-METILMETANAMINA, 1-{1-(2-FLUOROFENIL-3-IL)-5-[(4-METOXIFENIL)SULFONIL]-1H-PIRAZOL-3-IL}-N-METILMETANAMINA, 1-{1-(2-FLUOROPIRIDIN-3-IL)-5-[(3-METILFENIL)SULFONIL]-1H-PIRAZOL-3-IL}-N-METILMETANAMINA, ENTRE OTROS. TAMBIEN ESTA RELACIONADA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS INHIBEN LA BOMBA DE PROTONES SUPRIMIENDO LA SECRECION DE ACIDO GASTRICO Y SON UTILES EN EL TRATAMIENTO DE ULCERA PEPTICA, DISPEPSIA FUNCIONAL, ENFERMEDAD DE REFLUJO, GASTRITIS, ENTRE OTRAS
