An exemplary system includes a navigation system, an imaging system, and a data acquisition and analysis system. The exemplary system provides actively guidance for ultrasound image acquisition based on position information provided by the navigation system at different times (e.g., before and after an interventional procedure), to ensure that image data is collected at the same location within the object of interest (e.g., a target region of the interventional procedure) using the same probe posture (e.g., location and/or orientation).