<；p>； Non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A are provided. In addition, methods are provided to use VEGF-A-binding non-naturally occurring CKPs, including diagnostic and therapeutic compositions and methods. Non-naturally occurring CKPs that bind to low-density lipoprotein receptor-related protein 6 (LRP6) are also provided .nbsp； <；/p>；<；p>；Se proporcionan pé；ptidos de nudo de cistina (CKP) de origen no natural que se unen a VEGF-A. Ademá；s, se proporcionan mé；todos para utilizar los CKP de origen no natural que se unen a VEGF-A, incluidas composiciones y mé；todos de diagnó；stico y terapé；uticos. Tambié；n se proporcionan CKP de origen no natural que se unen a la proteí；na relacionada con el receptor de lipoproteí；na de baja densidad 6 (LRP6). ；<；/p>；
