SPLIT-CORE-PARTICLES FOR THE PRESENTATION OF FOREIGN MOLECULES, ESPECIALLY FOR VACCINE APPLICATIONS, AND METHOD FOR THEIR PRODUCTION

• 收藏
• 分享

专利权人:

发明人:

NASSAL, MICHAEL,SKAMEL, CLAUDIA,WALKER, ANDREAS

申请号：

MYPI 20090936

公开号：

MY146926A

申请日:

2007.07.12

申请国别(地区):

MY

年份:

2012

代理人:

摘要：

DISCLOSED ARE SPLIT-CORE CARRIER SUBSTANCE WHICH, AS SEPARATE POLYPEPTIDES, HAVE THE CORE N DOMAIN AND THE CORE C DOMAIN OF THE CORE PROTEIN OF A HEPATITIS B VIRUS AND AT LEAST ONE FOREIGN MOLECULE AGAINST WHICH AN IMMUNE RESPONSE IS TO BE INDUCED. ACCORDING TO THE INVENTION, THE FOREIGN MOLECULE, ESPECIALLY THE HETEROLOGOUS FOREIGN AMINO ACID SEQUENCE, IS FUSED TO THE C TERMINUS OF THE CORE N DOMAIN OR TO THE N TERMINUS OF THE CORE C DOMAIN AND THE CORE PROTEIN CAN FROM CAPSID-LIKE PARTICLES. THE INVENTION ALSO RELATES TO THE ASSOCIATED PRODUCTION METHOD.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/