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Split-core-particles for the presentation of foreign molecules, especially for vaccine applications, and method for their production
专利权人:
Claudia Skamel;Andreas Walker;Michael Nassal
发明人:
Michael Nassal,Claudia Skamel,Andreas Walker
申请号:
US12440454
公开号:
US08282932B2
申请日:
2007.07.12
申请国别(地区):
US
年份:
2012
代理人:
摘要:
Disclosed are split-core carrier substance which, as separate polypeptide, have the core N domain and the core C domain of the core protein of a hepatitis B virus and at least one foreign molecule against which an immune response is to be induced. According to the invention, the foreign molecule, especially the heterologous foreign amino acid sequence, is fused to the C terminus or the core N domain or to the N terminus of the core C domain and the core protein can form capsid-like particles. The invention also relates to the associated production method.
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中国工程科技知识中心
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