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Tricyclic oxazolidinone antibiotic compounds
专利权人:
ACTELION PHARMACEUTICALS LTD.
发明人:
HUBSCHWERLEN, CHRISTIAN,RITZ, DANIEL,RUEEDI, GEORG,SURIVET, JEAN-PHILIPPE,ZUMBRUNN ACKLIN, CORNELIA
申请号:
ES09740759
公开号:
ES2533217T3
申请日:
2009.10.06
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
A compound of formula I ** Formula ** in which "-----" is a bond or is absent; R0 represents H or, if "-----" is a bond, it can also represent (C1-C3) alkoxy, R1 represents H, halogen, cyano, (C1-C3) alkyl or ethynyl; U represents CH or N when "----" is a link, or, if "---" is absent, U represents CH2, NH or NR9; V represents CH, CR6 or N; R2 represents H, (C1-C3) alkylcarbonyl or a group of the formula -CH2-R3; R3 represents H, (C1-C3) alkyl or hydroxy (C1-C3) alkyl; R4 represents H or, in cases where n is not 0 and R5 is H, it can also represent OH; R5 represents H, (C1-C3) alkyl, hydroxy (C1-C3) alkyl, amino (C1-C3) alkyl, (C1-C3) alkoxy (C1-C3) alkyl, carboxy or (C1-C3) alkoxycarbonyl; R6 represents hydroxyalkyl (C1-C3), carboxy, alkoxycarbonyl (C1-C3) or a group - (CH2) q-NR7R8 in which q is 1, 2 or 3 and each of R7 and R8 independently represents H or alkyl ( C1-C3) or R7 and R8 together with the nitrogen atom which carries them a pyrrolidinyl, piperidinyl, morpholinyl or thiomorpholinyl ring; R9 represents (C1-C3) alkyl, 2-hydroxy-ethyl, 2-hydroxy-propyl or 3-hydroxy-propyl; A represents - (CH2) p-, -CH2CH2CH (OH) - or -COCH2CH (OH) -; G represents a phenyl group that is substituted once or twice at the target position and / or for substituents independently selected from (C1-C4) alkyl, (C1-C3) alkoxy and a halogen, or G is a group that it has one of the formulas G1 and G2 indicated below in which Q is O or S and X is CH or N; and each of Y1, Y2 and Y3 represents CH, or each of Y1 and Y3 represents CH and Y2 represents N, or Y1 represents N, Y2 represents CH or N and Y3 represents CH, or each of Y1 and Y2 represents CH and Y3 represents N; and n is 0 when A represents -CH2CH2CH (OH) - or -COCH2CH (OH) -, and n is 0, 1 or 2 when A represents (CH2) p, where p is 1, 2, 3 or 4, with the condition that the sum of n and p is then 2, 3 or 4; or a pharmaceutically acceptable salt of said compound.Un compuesto de fórmula I**Fórmula** en la que "-----" es un enlace o e
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