Seog Bae OH,Sung Jun JUNG,Ge Hoon CHUNG,Yong Ho KIM
申请号：
US13494859
公开号：
US20130150455A1
申请日:
2012.06.12
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates to a pharmaceutical composition for selectively treating mechanical allodynia, which provides eugenol or a pharmaceutically acceptable salt thereof at a concentration lower than that which would inhibit voltage-gated sodium channels (VGSCs), a pharmaceutical composition for blocking hyperpolarization-activated current (Ih), and a transdermal preparation for treating mechanical allodynia comprising the composition.Even though administered at a concentration lower than that which would inhibit VGSCs, the eugenol of the present invention inhibits Ih in a cAMP or G-protein coupled receptor (GPCR) independent manner, thereby selectively ameliorating mechanical allodynia. Therefore, when the eugenol of the present invention is formulated into a transdermal preparation to be provided at a concentration lower than that which would inhibit VGSCs, and directly applied to the wound lesion, it can be used as a pharmaceutical composition capable of selectively treating mechanical allodynia.
