MICHELS, MARTIN,FOLLMANN, MARKUS,VAKALOPOULOS, ALEXANDROS,ZIMMERMANN, KATJA,TEUSCH, NICOLE,LOBELL, MARIO,BIERER, DONALD,ENGEL, KAREN,KISSEL, MARIA
申请号：
PE2012000384
公开号：
PE20121392A1
申请日:
2010.10.01
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
It refers to the compound in formula (I) substituted by 3,5-dichloro-4 - (1h-indazol-5-il) - 2,6-dimethyl-1,4-dihydropyridine-fluorine, R1 is h, fluorine, methyl or ethyl； R2 is methyl, difluoro or trifluoroethane； R3 is h or fluorine； R4 is h, methyl or ethyl； R5 is h or methyl. 1-1-dihydropyridine-1-1-1-1-1-1-1-1-1-1-1-1-1-1-fluoro-1,4-dihydropyridine-3,5-nitrogen dioxide；There are others He also mentioned a preparatory process and a pharmaceutical composer. These compounds are inhibitors of thyroid protein c-met and are useful in cancer treatment.SE REFIERE A COMPUESTOS DERIVADOS DE 3,5-DICIANO-4-(1H-INDAZOL-5-IL)-2,6-DIMETIL-1,4-DIHIDROPIRIDINA FLUORO-SUSTITUIDOS DE FORMULA (I) DONDE R1 ES H, FLUORO, METILO O ETILO； R2 ES METILO, DIFLUOROMETILO O TRIFLUOROMETILO； R3 ES H O FLUORO； R4 ES H, METILO O ETILO； R5 ES H O METILO. SON COMPUESTOS PREFERIDOS: rac-2-METIL-4-(3-METIL-1H-INDAZOL-5-IL)-6-(TRIFLUOROMETIL)-1,4-DIHIDROPIRIDINA-3,5-DICARBONITRILO； (4R)-2-(DIFLUOROMETIL)-4-(6-FLUORO-3-METIL-1H-INDAZOL-5-IL)-6-METIL-1,4-DIHIDROPIRIDINA-3,5-DICARBONITRILO； 2,6-BIS(DIFLUOROMETIL)-4-(6-FLUORO-3-METIL-1H-INDAZOL-5-IL)-1,4-DIHIDROPIRIDINA-3,5-DICARBONITRILO； ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA PROTEINA TIROSINA QUINASA c-Met SIENDO UTILES EN EL TRATAMIENTO DE CANCER
