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substituted fluorine 3,5-dicyano-4- (1h-indazol-5-yl) -2,6-dimethyl-1,4-dihydropyridine derivatives and their methods of use
专利权人:
BAYER PHARMA AKTIENGESELLSCHAFT
发明人:
ALEXANDROS VAKALOPOULOS,DONALD BIERER,KAREN ENGEL,KATJA ZIMMERMANN,MARIA KISSEL,MARIO LOBELL,MARKUS FOLLMANN,MARTIN MICHELS,NICOLE TEUSCH
申请号:
BR112012006842
公开号:
BR112012006842A2
申请日:
2010.10.01
申请国别(地区):
BR
年份:
2016
代理人:
摘要:
fluorine substituted 3,5-dicyano-4- (1h-indazol-5-yl) 2,6-dimethyl-1,4-dihydropyridine derivatives and their methods of use. The present invention relates to novel fluor substituted substituted 3,5-dicyano-4- (1h-indazol-5-yl) 2,6-dimethyl 1,4-dihydropyridine derivatives having protein tyrosine kinase inhibitory activities, a process for their production and use for the treatment of c-met-mediated diseases or conditions mediated by c-met cancer and other proliferative diseases.derivados de 3,5-diciano-4-(1h-indazol-5-il)2,6-dimetil-1,4-dihidropiridina fluor substituidos e seus metodos de uso. a presente invenção se refere a novos derivados de 3,5-diciano-4-(1h-indazol-5-il) 2,6-dimetil 1,4-dihidropiridina fluor substituído tendo atividades inibidora da proteina tirosina quinase, a um processo para a sua produção e ao seus uso para o tratamento de doenças mediadas por c-met ou condições mediadas por c-met câncer e outras doenças proliferativas.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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