A plasina-generation device for applying plasma to a human body, having a reservoir containing a gas, a plasma zone in fluid connection with the reservoir, and means for generating a plasma by electrical discharge in the plasma zone. The gas has a composition of 92% to 99.5% Helium and 0.5% to 8% Argon; or 95% to 99.5% Helium and 1% to 20% Neon; or 99.95% to 99.99% Helium and 0.01% to 0.05% Oxygen.