Prather, Randall S.,Whitworth, Kristin,Wells, Kevin
申请号：
AU2018256670
公开号：
AU2018256670A1
申请日:
2018.11.02
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
#$%^&*AU2018256670A120181206.pdf#####Abstract: The disclosure relates to genetically modified swine wherein at least one allele of a SIGLECI gene has been inactivated and/or at least one allele of a CD 163 gene has been inactivated. Genetically modified swine having both alleles of the SIGLECI gene and/or both alleles CD 163 gene inactivated are resistant to porcine reproductive and respiratory syndrome virus (PRRSV). Methods for producing such transgenic swine are also provided.WO 2012/158828 PCT/US2012/038193 1/6 FIG. 1 Organization of the sialoadhesin gene and targeting vector design. A) 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 1 kb Human 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 1920 21 Mouse C) Gln Thr Thr Trp Gly Val Ser Ser Pro Lys Asn Val Gln Gly Leu Ser Gly Ser gc cag acc aca tgg ggt gtc tcc agt ccc aag aat gtg cag ggc ttg tcg gga tcc Cys Leu Leu Ile Pro Cys Ile Phe Ser Tyr Pro Ala Asp Val Pro Val Ser Asn Gly tgc ctg ctc att ccc tgc atc ttc agc tac cct gcc gat gtc cca gtg tcc aat ggc Ile Thr Ala Trp Tyr Tyr Asp Tyr Ser Gly Lys Arg Gln Val Val Ile His Ser atc aca gcc a tgg tac tat gac tac tcg ggc aag cgg cag gtg gta atc cac tca Gly Asp Pro Lys Leu Val Asp Lys Arg Phe Arg Gly Arg Ala Glu Leu Met Gly Asn ggg gac ccc aag ctg gtg gac aag cgt ttc agg ggt cga gct gaa ctg atg ggg aac Met Asp His Lys Val Cys Asn Leu Leu Leu Lys Asp Leu Lys Pro Glu Asp Ser Gly atg gac cac aag gtg tgc aac ctg ttg ctc aaa gac ttg aag cct gaa gac tct ggc Thr Tyr Phe r Phe Glu Ile Ser Asp Ser Asn rg Trp Leu Val Lys Gly acc tac ac ttc c ttt gag atc agt gat agc aac gc tgg tta gtc aaa ggc Thr Thr Val Thr Val Thr acc acg gtc act gtg aca a D) 4 PGK -R NEO ....... n... ... 1......
