Specific binding proteins and uses thereof

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专利权人:

LUDWIG INSTITUTE FOR CANCER RESEARCH LTD.

发明人:

Panousis Con,Scott Andrew Mark,Ritter Gerd,Stockert Elizabeth,Huang Huei-Jen Su,Renner Christoph,Cavenee Webster K,Nice Edouard Collins,Jonhs Terrance Grant,Murray Anne,Burgess Antony Wilks,Jungbluth

申请号：

NZ71676210

公开号：

NZ716762A

申请日:

2010.02.17

申请国别(地区):

NZ

年份:

2017

代理人:

摘要：

Discloses an immunoconjugate comprising an isolated anti-Epidermal Growth Factor Receptor (EGFR) antibody attached to a cytotoxic agent, wherein the anti-EGFR antibody is an IgG1 isotype, comprises a heavy chain comprising a heavy chain variable region comprising the amino acid sequence set forth in SEQ ID NO: 164, and comprises a kappa light chain comprising a light chain variable region comprising the amino acid sequence set forth in SEQ ID NO: 166, wherein the antibody is expressed in a mammalian cell, wherein the sequences are as defined in the complete specification.

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