Inhibitors of Aβ and synuclein aggregation

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专利权人:

ザ・フェインスタイン・インスティチュート・フォー・メディカル・リサーチ

发明人:

オール－アベド、ユウセフ,オール-アベド、ユウセフ

申请号：

JP2009518170

公开号：

JP5432710B2

申请日:

2007.06.22

申请国别(地区):

JP

年份:

2014

代理人:

摘要：

Provided are methods of inhibiting aggregation of amyloid-beta (A&bgr；) or accumulation of aggregated A&bgr； using certain guanylhydrazone compounds. Also provided are methods of treating or preventing an amyloid-related disease in a mammal, methods of treating a subject having Alzheimer's disease, methods of treating a subject at risk for Alzheimer's disease, methods of inhibiting aggregation or accumulation of a synuclein, methods of treating a subject having a disease at least partially mediated by synuclein, methods of treating a subject at risk for a disease at least partially mediated by synuclein, and methods of inhibiting aggregation or accumulation of a protein involved in a conformational disease, using the guanylhydrazone compounds.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/