A catheter connector and securement device system includes a connector seated within a securement device. The securement device includes a lower shell member having a perimeter wall defining an interior cradle space that conforms to the connector body. A cover member is hinged to the lower shell member at a hinge line and is movable from an open position for insertion and removal of the connector to a closed position wherein the cover member releasably latches to the lower shell member to retain the connector within the lower shell member. A catheter retention device may be spaced from the perimeter wall.