In some embodiments, the present invention provides a method of treating cancer, comprising an agent that inhibits the expression or activity of NEDD4-1 (neural precursor cell expressed developmentally down-regulated protein 4) and WWP1 (WW domain- There is provided a method comprising administering to a subject having cancer an effective amount of an agent that inhibits the expression or activity of containing protein-1).いくつかの態様において、本発明は、がんを処置する方法であって、NEDD4-1(neural precursor cell expressed developmentally down-regulated protein 4)の発現または活性を阻害する作用物質およびWWP1(WW domain-containing protein-1)の発現または活性を阻害する作用物質の有効量を、がんを有する対象に投与する段階を含む方法を提供する。