The present invention relates to RSPO-binding agents, particularly RSPO3-binding agents and methods of using the agents for treating diseases such as cancer. The present invention provides antibodies that specifically bind human RSPO3 proteins and modulate β-catenin activity. The present invention further provides methods of using agents that modulate the activity of RSPO3 proteins and inhibit tumor growth. Also described are methods of treating cancer comprising administering a therapeutically effect amount of an agent or antibody of the present invention to a patient having a tumor or cancer.本發明關於RSPO結合劑，特別是RSPO3結合劑及使用該等劑以治療疾病(諸如癌症)之方法。本發明提供與人RSPO3蛋白特異性結合且調節β-連環蛋白活性之抗體。本發明另提供使用能調節RSPO3蛋白之活性且抑制腫瘤生長之劑的方法。本發明亦描述治療癌症之方法，該等方法包含對患有腫瘤或癌症之病患投予治療有效量之本發明之劑或抗體。
