It refers to a compound made of uracilo derivatives, which is replaced by formula (I) of bicycle, wherein R1, R2 and R3 are compounds of this definition. Benzene, diphenyl, diphenyl, diphenyl, diphenyl, diphenyl, diphenyl, diphenyl, diphenyl, triphenyl-1h-benzodiazo-5-il-2, 4-diazo-1, 2, 3, 4-tetrahydropyridine-5-ethyl carboxylic acid；There are others He also mentioned a drug synthesis and preparation process. These compounds are quinase inhibitors for the treatment of heart failure, pulmonary hypertension and asthma.SE REFIERE A COMPUESTOS DERIVADOS DE URACILO SUSTITUIDOS BICICLICAMENTE DE FORMULA (I) DONDE R1, R2 Y R3 SON COMO SE DEFINEN EN LA PRESENTE. SON COMPUESTOS PREFERIDOS: 3-[2-CLORO-3-(TRIFLUOROMETIL)BENCIL]-1-(3-(CICLOPROPILMETIL)-1-METIL-2-OXO-2,3-DIHIDRO-1H-BENCIMIDAZOL-5-IL)-2,4-DIOXO-1,2,3,4-TETRAHIDROPIRIMIDINA-5-CARBOXILATO DE ETILO； 3-[2-CLORO-3-(TRIFLUOROMETIL)BENCIL]-1-(1-METIL-3-(OXETAN-2-ILMETIL)-2-OXO-2,3-DIHIDRO-1H-BENCIMIDAZOL-5-IL)-2,4-DIOXO-1,2,3,4-TETRAHIDROPIRIMIDINA-5-CARBOXILATO DE ETILO； ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y A PROCEDIMIENTOS DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE QUINASA UTILES PARA EL TRATAMIENTO DE INSUFICIENCIA CARDIACA, HIPERTENSION PULMONAR, ASMA
