PROBLEM TO BE SOLVED: To provide an MMPs activity inhibitor, a skin sagging prevention or improvement agent, a wrinkle prevention or improvement agent, a skin aging prevention or improvement agent, or the like.SOLUTION: There are provided a matrix metalloprotease activity inhibitor, a skin sagging prevention or improvement agent, a wrinkle prevention or improvement agent, a skin aging prevention or improvement agent, and a skin external preparation, containing one or more plants selected from Cranesbill and Dogwood Bark American or an extract thereof as an active ingredient.COPYRIGHT: (C)2014,JPO&INPIT【課題】 MMPs活性阻害剤、皮膚のタルミ予防又は改善剤、シワ予防又は改善剤、皮膚老化予防又は改善剤等の提供。【解決手段】 Cranesbill及びDogwood Bark Americanから選ばれる一種以上の植物又はその抽出物を有効成分とするマトリックスメタロプロテアーゼ活性阻害剤、皮膚のタルミ予防又は改善剤、シワ予防又は改善剤、皮膚老化予防又は改善剤、皮膚外用剤。【選択図】なし
