The present invention relates to the use of a substrate metalloproteinase in the skin comprising topical application to the skin surface of a composition comprising a ratio effective to the synergistic action of the amount of hydroxamic acid, its salt and / or complex thereof and the amount of glycol Lt； / RTI >； activity. In some embodiments, the ratio of the weight percent of hydroxamic acid, its salt and / or complex thereof to the weight percent of glycol is about 1 to 1.4 (based on the weight of the total composition)； About 1 to 3； Is selected from a ratio of about 1 to 5. Also included are related methods, including methods of preventing or reducing the appearance of aging of the skin surface, the method comprising administering to a subject in need thereof a ratio effective to the synergistic action of the amount of hydroxy triacid, its salt and / or complex thereof and the amount of glycol <； / RTI >； comprising topically applying the composition to a skin surface； Methods of increasing the enzymatic inhibition potential of glycols include combining at least one glycol with a synergistically effective amount of hydroxamic acid, a salt thereof and / or a combination thereof to form a synergistic mixture, Enzymatic inhibition potential of the synergistic mixture is greater than the enzymatic inhibition potential of glycol alone or hardroxenic acid alone. Within the scope of the present invention there is also provided a pharmaceutical composition which inhibits the activity of matrix metalloproteinases (MMPs) in the skin, comprising a ratio effective to the synergistic action of the amount of hydroxamic acid, its salt and / or complex thereof and the amount of glycol Anti-aging compositions are contemplated. In some embodiments, the ratio is about 1: 1: 4, about 1: 3； (By weight of total composition) of about 1 to 5 percent by weight.본 발명은 히드록삼산, 그 염 및/또는 그것들의 복합물의 양 및 글리콜의 양의 상승작용에 유효한 비율을 포함하는 조성물의 피부 표면으로의 국소 적용을 포함하는 피부 내의 기질 메탈로프로테이나아제의 활성을 억제하는 방법
