#$%^&*AU2017251841A120171123.pdf#####Abstract Provided herein are polyglycol based pre-formulations for forming hydrogel comprising at least one nucleophilic compound, at least one electrophilic compound and optionally a therapeutic agent and/or viscosity enhancer. In some embodiments, the biocompatible hydrogel polymer covers a wound in a mammal and adheres to the surrounding skin tissue. In other embodiments, the hydro gel polymer is delivered into a joint space to treat joint disease or navicular disease