Provided are multi-arm polymer conjugates of Toll-Like Receptor ("TLR") agonists such as TLR 7/8 agonists, as well as related compositions, and methods of making and using such conjugates. Exemplary conjugates are encompassed by Formula I: (I) or a pharmaceutically acceptable salt form thereof, where R, taken together with each Q, is a residue of a polyol, polythiol, or polyamine bearing from 3 to about 50 hydroxyl, thiol, or amino groups； each Q is a linker selected from oxygen, sulfur and -NH； each POLY is independently a water-soluble, non-peptidic polymer； each Xr is independently a linkage-containing spacer moiety； q is a positive integer from 3 to about 50； and each TLR 7/8 AG is a Toll-like receptor 7/8 agonist. Also provided is a method of administering to a patient having cancer (a) an IL-2Rβ-activating amount of a long-acting, IL-2Rβ-selective agonist； and (b) a Toll-like receptor agonist such as a conjugate as described above, as well as related compositions, kits and methods.
