Massachusetts Institute of Technology;Childern's Medical Center Corporation
发明人:
Ma, Minglin,Anderson, Daniel G.,Langer, Robert S.,Veiseh, Omid,Vegas, Arturo Jose,Doloff, Joshua Charles,Chen, Delai,Kastrup, Christian J.
申请号：
AU2014236296
公开号：
AU2014236296A1
申请日:
2014.03.14
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
Biomedical devices for implantation with decreased pericapsular fibrotic overgrowth are disclosed. The device includes biocompatible materials and has specific characteristics that allow the device to elicit less of a fibrotic reaction after implantation than the same device lacking one or more of these characteristic that are present on the device. Biocompatible hydrogel capsules encapsulating mammalian cells having a diameter of greater than 1 mm, and optionally a cell free core, are disclosed which have reduced fibrotic overgrowth after implantation in a subject. Methods of treating a disease in a subject are also disclosed that involve administering a therapeutically effective amount of the disclosed encapsulated cells to the subject.
