Massachusetts Institute of Technology;The Children's Medical Center Corporation
发明人:
Minglin Ma,Daniel G. Anderson,Robert S. Langer,Omid Veiseh,Arturo Jose Vegas,Joshua Charles Doloff,Delai Chen,Christian J. Kastrup
申请号：
US15573926
公开号：
US20180353643A1
申请日:
2016.05.17
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Biomedical devices for implantation with decreased pericapsular fibrotic overgrowth are disclosed. The device includes biocompatible materials and has specific characteristics that allow the device to elicit less of a fibrotic reaction after implantation than the same device lacking one or more of these characteristic that are present on the device. Biocompatible hydrogel capsules encapsulating mammalian cells having a diameter of greater than 1 mm, and optionally a cell free core, are disclosed which have reduced fibrotic overgrowth after implantation in a subject. Methods of treating a disease in a subject are also disclosed that involve administering a therapeutically effective amount of the disclosed encapsulated cells to the subject.
