UCL BUSINESS PLC;ANDERSON John;FISHER Jonathan;GUSTAFSSON Kenth;PULE Martin
发明人:
ANDERSON John,FISHER Jonathan,GUSTAFSSON Kenth,PULE Martin
申请号:
IL25518617
公开号:
IL255186D0
申请日:
2017.10.22
申请国别(地区):
IL
年份:
2017
代理人:
摘要:
The present invention provides a T cell which expresses a gamma-delta T cell receptor (TCR) and a chimeric antigen receptor (CAR), wherein the CAR comprises: an antigen binding domain; a transmembrane domain; and a co-stimulatory intracellular signalling domain; wherein the intracellular signalling domain provides a co-stimulatory signal to the T cell following binding of antigen to the antigen binding domain.