TEWARI, DIVYA,TITOVA, YEVGENIYA, A.,BEISSNER, BRAD,DURIG, THOMAS
申请号：
EP14779334
公开号：
EP2968580A4
申请日:
2014.03.12
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
An excipient composition having good bulk density and improved flow characteristics is provided. The present invention particularly provides a coprocessed excipient composition and a method of producing the same. The coprocessed excipient comprises cellulose derived polymer and a deagglomerated coprocessing agent. The coprocessing agent is fumed silica, colloidal silica or silicon dioxide. The coprocessed excipient is prepared in a continuous process and has excellent compactability and improved flow property as measured by Johanson flow rate number increase from 1.1 to 5.0 fold, is characterized by a Brookfield cohesion factor of less than 0.2 kPa and a bulk density of at least 0.249 g/ml.
