TEWARI DIVYA,TITOVA YEVGENIYA A,BEISSNER BRAD,DURIG THOMAS
申请号：
IN6906/DELNP/2015
公开号：
IN2015DN06906A
申请日:
2015.08.05
申请国别(地区):
IN
年份:
2015
代理人:
摘要：
An excipient composition having good bulk density and improved flow characteristics is provided. The present invention particularly provides a coprocessed excipient composition and a method of producing the same. The coprocessed excipient comprises cellulose derived polymer and a deagglomerated coprocessing agent. The coprocessing agent is fumed silica colloidal silica or silicon dioxide. The coprocessed excipient is prepared in a continuous process and has excellent compactability and improved flow property as measured by Johanson flow rate number increase from 1.1 to 5.0 fold is characterized by a Brookfield cohesion factor of less than 0.2 kPa and a bulk density of at least 0.249 g/ml.
