Divya TEWARI,Yevgeniya A. TITOVA,Brad BEISSNER,Thomas DURIG
申请号：
US14764921
公开号：
US20150359895A1
申请日:
2014.03.12
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention provides a coprocessed excipient composition and a method of producing the same. The coprocessed excipient comprises vinyl lactam derived polymer and a deagglomerated coprocessing agent. The coprocessing agent is fumed silica, colloidal silica or silicon dioxide. The coprocessed excipient is prepared by a continuous process and has a Brookfield cohesion of less than 0.12 kPa, a bulk density of at least 0.249 gram/milliliter and a flow property as measured by Johanson flow rate number increase from 1.1 to 5.0 fold.
