SHUM, THOMAS C.T.,GOTTSCHALK, STEPHEN M.G.,OMER, BILAL,ROONEY, CLIONA M.
申请号：
CA3034873
公开号：
CA3034873A1
申请日:
2017.08.11
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Embodiments of the disclosure include methods and compositions for enhancing expansion of immune cells for immunotherapy. In particular embodiments, immune cells, such as T-cells, express a constitutively active cytokine receptor in which the transmembrane and endodomains are able to provide an activating signal separately from any input to the corresponding exodomain to which they are operably linked. In specific embodiments, the transmembrane and endodomain from IL-7Ra is utilized with the exodomain of CD34.
