A dispenser having a cartridge holder. Said cartridge holder has at least oneguide and/ortwist prevention means for a cartridge and/or a cartridge receptacle. Thecartridge holdercomprises a fastening flange which engages around the cartridge receptacle ina form-fittingand/or force-fitting manner during or after insertion into the holder. Thefastening flangecomprises a release mechanism, which is configured such that actuation of thereleasemechanism results in the fastening flange engaging around the cartridgereceptacle such thata relative movement between the cartridge receptacle and the release elementin contactwith the piercing means is generated, with the result that the piercing meansis transferredfrom the retracted position into the extended position.
