In one aspect the invention relates to substituted substituted 2 hydroxy 4 (2 (phenylsulfonamido)acetamido)benzoic acid analogs derivatives thereof and related compounds which are useful as inhibitors of STAT protein activity synthetic methods for making the compounds pharmaceutical compositions comprising the compounds and methods of treating disorders of uncontrolled cellular proliferation associated with a STAT protein activity dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.