NELLO MAINOLFI,JAMES J. POWERS,MICHAEL H. SERRANO-WU,CHUN ZHANG,RAJESHRI GANESH KARKI,XUE LIANG,JIAN DING,TOSHIO KAWANAMI,CHARLES BABU,CHRISTOPHER MICHAEL ADAMS,TAKERU EHARA,KEITH JENDZA,MICHAEL PAUL
申请号：
ARP130101533
公开号：
AR090945A1
申请日:
2013.05.06
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
A method for Manufacturing the compounds of the present, and their Therapeutic uses. It also provides a combination of pharmacologically Active agents and a Pharmaceutical composition.Claim 1: a Compound, or Salt or a taut u00f3mero thereof, according to the formula (1), where u207b u207b u207b u207b u207b is a simple link or double； X is n or CH, and N (H) o or s； R is an occurrence of cyano and other occurrences of R it is r u2074 r u00b9 is Hydrogen or Halogen, alkyl, hydroxyl, C u2081 u208b u2086, alquenilo c u2082 u208b u2086, cycloalkyl c u2083 u208b u2086 c u2081 u208b u2086 Halo alkyl, alkoxyl, alkyl c u2081 u208b u2086 c u2081 u208b u2086, Hydroxy, amino alkyl c u2081 u208b u2086,C u2081 u208b u2086alquilo c u2081 u208b u2086 c u2081 u208b u2086alcoxilo c u2081 u208b u2086 alkoxy, alkoxy, cicloalquil c u2083 u208b u2086alcoxilo c u2081 u208b u2086, Halo - S (o) c u2081 u208b u2086 alkoxyl, alkyl u209a c u2081 u208b u2086, ch u2082nhc (OR) alkyl c u2081 u208b u2084 or och u2082c (OR) r u2077； p is 0, 1 or 2； R u00b2 is c u2081 u208b u2086 c u2081 u208b u2086 alkyl, alkoxyl, alkyl Hydroxy C u2081 u208b u2086 r u00b3 is Hydrogen or Halogen, halogen, alkyl, cyano, c u2081 u208b u2084, Halo c u2081 u208b u2084 ch u2082c (or alkyl, phenyl or heteroaryl) r u2077, 5 or 6 members that has 1,2 or 3 hetero Ring independently selected from N, o or s, where the phenyl or heteroaryl is optionally replaced by 0, 1, or 2 c u2081 u208b u2084 alkyl groups, and where haloalquilo optionally substituted by alkyl and hydroxyl r u2074 is 0 OR 1； 0, 1, or 2 replacement At each occurrence, independently selected from alkyl and Halogen c u2081 u208b u2086 r u2075 is Hydrogen；C u2081 u208b u2086 alkyl, cycloalkyl c u2083 u208b u2086 c u2081 u208b u2086 Halo alkyl, phenyl or heteroaryl 5 or 6 members who have 1, 2 or 3 hetero Ring independently selected from N, o or s； or r u00b3 and r u2075 taken in combination form a Group - - - - ch u2082 ch u2082 ch u2082 or - N (H) - dival
