LOUTHERBACK, Kevin D.,BRONEVETSKY, Yelena,BEEMILLER, Peter J.,WANG, Xiaohua,CHAPMAN, Kevin T.
申请号：
EP17831997
公开号：
EP3487510A4
申请日:
2017.07.21
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
Methods of sorting T lymphocytes in a microfluidic device are provided. The methods can include flowing a fluid sample comprising T lymphocytes through a region of a microfluidic device that contains an array of posts. The array of posts can be configured to have a critical size (Dc) that separates activated T lymphocytes from naïve T lymphocytes. Also provided are microfluidic devices having an array of posts configured to separate activated T lymphocytes from naïve T lymphocytes, compositions enriched for T lymphocytes, particularly activated T lymphocytes that are known to be reactive to an antigen of interest, and methods of treating subjects suffering from a pathogenic disorder or cancer by administering such compositions.
