LOUTHERBACK, KEVIN D.,BRONEVETSKY, YELENA,BEEMILLER, PETER J.,WANG, XIAOHUA,CHAPMAN, KEVIN T.
申请号：
CA3030748
公开号：
CA3030748A1
申请日:
2017.07.21
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Methods of sorting T lymphocytes in a microfluidic device are provided. The methods can include flowing a fluid sample comprising T lymphocytes through a region of a microfluidic device that contains an array of posts. The array of posts can be configured to have a critical size (Dc) that separates activated T lymphocytes from nave T lymphocytes. Also provided are microfluidic devices having an array of posts configured to separate activated T lymphocytes from nave T lymphocytes, compositions enriched for T lymphocytes, particularly activated T lymphocytes that are known to be reactive to an antigen of interest, and methods of treating subjects suffering from a pathogenic disorder or cancer by administering such compositions.
