University Of Central Florida Research Foundation; Inc.
发明人:
SANTRA, Swadeshmukul
申请号：
ES09832240
公开号：
ES2598531T3
申请日:
2009.12.10
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A method for synthesizing a nanoformulación based on silica containing antibacterial and antifungal agents using a sol-gel process in a single vessel and catalyzed by acid, comprising the steps of: selecting a reaction vessel containing an acidic reaction medium adding tetraethoxysilane (TEOS), water, ethanol and an antibacterial or antifungal agent containing copper ions in the reaction vessel, with the acidic medium to form a mixture I allowing the reaction mixture I continue for approximately one hour to facilitate the formation of a plurality of nanoparticles based on silica adding a neutralizing agent after the formation of a plurality of nanoparticles to adjust the pH of the reaction mixture to about 7.0 allowing the neutralized reaction mixture of I proceed for about 12 hours, preferably overnight, to allow gelation to occur, and form a structure consisting of interconnected nanogel nanoparticles and collecting a porous silica based nanogel having antibacterial and antifungal agents together in a plurality of interconnected nanoparticles nanogel wherein the antibacterial or antifungal agent is a plurality of copper ions (Cu) coming from a copper compound wherein the plurality of interconnected nanoparticles nanogel contain - a plurality of Cu ions electrostatically attached to the core nanoparticle, - a plurality of nanocrystals incorporated Cu including at least Cu2O, - a plurality of Cu ions covalently attached to a silica matrix with a surface of the hydrated cortex nanopores of the nanoparticle and nanogel porous channels, and - a plurality of oxide / hydroxide Cu as nanoclusters / nanoparticles attached to the surface of the nanoparticle.Un método para sintetizar una nanoformulación a base de sílice que contiene agentes antibacterianos y antifúngicos usando un proceso sol-gel en un solo recipiente y catalizado por ácido, que comprende las etapas de: selección de un recipiente de reacción que contiene un medio de reacción ácido adición de tetraetoxisilan
