George F. Schreiner;Sundeep Dugar;Cyrus K. Becker;Dinesh Mahajan
发明人:
Cyrus K. Becker,George F. Schreiner,Sundeep Dugar,Dinesh Mahajan
申请号：
US14237167
公开号：
US09187448B2
申请日:
2012.08.06
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to compounds, compositions, and methods for treatment of conditions related to mitochondrial function. In various aspects, the present invention comprises administering one or more epicatechin derivatives in an amount effective to stimulate mitochondrial function in cells. The compounds, compositions, and methods described herein provide for reducing infarct size in the heart following permanent ischemia or ischemia/reperfusion event or method for delaying, attenuating or preventing adverse cardiac remodeling, and can assist in prevention of impaired mitochondria biogenesis and thus prevention of the consequences of impaired mitochondrial biogenesis in various diseases and conditions, as well as provide for the active therapy of mitochondrial depletion that may have already occurred.
