CHEN, YOUNG K.,陈 扬Ｋ,陳 揚Ｋ,WALLACE, MICHAEL BRENNAN,华勒斯 麦可布雷南,華勒斯 麥可布雷南,陈 扬K,陳 揚K,华勒斯 麦可布雷南,華勒斯 麥可布雷南
申请号：
TW105143541
公开号：
TW201722930A
申请日:
2016.12.28
申请国别(地区):
TW
年份:
2017
代理人:
摘要：
The present disclosure relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyridine derivative compounds and pharmaceutical compositions comprising these compounds. The subject compounds and compositions are useful for inhibition of at least one histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer, or melanoma and the like.本案大體係關於用於治療癌症及腫瘤疾病之組合物及方法。本文提供了經取代的吡啶衍生化合物及包含此等化合物之醫藥組合物。此等標的化合物及組合物係用於抑制至少一種組織蛋白去甲基酶。此外，此等標的化合物及組合物係用於治療癌症，諸如前列腺癌、乳癌、膀胱癌、肺癌、或黑色素瘤及類似者。
