The present disclosure relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyridine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.本發明概言之係關於用於治療癌症及贅瘤性疾病之組合物及方法。本文提供經取代之吡啶衍生化合物及包含該等化合物之醫藥組合物。該等標題化合物及組合物可用於抑制組織蛋白去甲基化酶。此外，該等標題化合物及組合物可用於治療癌症，例如前列腺癌、乳癌、膀胱癌、肺癌及/或黑色素瘤及諸如此類。
