Novel anti-cancer agents, including, but not limited to, antibodies and immunoconjugates, that bind to CD37 are provided. Methods of using the agents, antibodies, or immunoconjugates, such as methods of inhibiting tumor growth are further provided.本發明提供了新型抗癌劑,包括但不限於結合CD37的抗體和免疫共軛物。本發明還提供了使用所述製劑、抗體或免疫共軛物的方法,例如抑制腫瘤生長的方法。